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    Drug-drug interaction: Bactrim (sulfamethoxazole and trimethoprim) delays the hepatic metabolism of coumadin, thereby prolonging the inr/protime and bleeding risks. Read more See 1 more doctor answer The probiotics can affect your prothrombin time/inr so be sure to get your blood checked regularly and don't miss appointments! Many drugs, including bactrim, (sulfamethoxazole and trimethoprim) dislodge it from protein and increase the free (active) drug in the circulation. the dose can be adjusted to accommodate your use of probiotics as long as you're consistent in their use. Read more Although there has been no specific study to oppose their combined use, there is no practical reason and need for taking these 2 sets of both together. This usually results in a sharp spike in the inr and can lead to bleeding. Read more Hello Randy Yes you should have your INR checked while on Bactrim (sulfamethoxazole and trimethoprim). So, take one only based on clinical judgment with or without urine culture for specific selection with a timely follow-up. If you must take batrim, you may need to skip a dose or two of coumadin. Bactrim (sulfamethoxazole and trimethoprim) is a combination of sulfamethoxazole/trimethoprim. There is significant interaction with Coumadin (warfarin) and Sulfamethoxazole and moderate interaction with trimethoprim. Read more Always tell your prescribing physician & dispensing pharmacist everything you take, whether prescription or otc. Several drug-drug interaction checkers are available online. Sulfamethoxazole and Coumadin (warfarin) interaction can put you in risk of bleeding if you are elderly or have kidney dis. If so - there are no significant interactions (as long as you're not allergic). Also, I am assuming a medical provider told you to switch and start cipro (ciprofloxacin). The Official Warfarin "Oh Shit" Drug Interaction List — tl;dr pharmacy Clinically Significant Drug Interactions - American Family Physician Ciprofloxacin and warfarin Drug Interactions -
     
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