Concerns have been raised that tamoxifen may be associated with depression. To investigate this question, we examined the psychological effects of tamoxifen treatment for breast cancer prevention on women at different levels of risk for clinical depression who were enrolled in the National Surgical Adjuvant Breast and Bowel Project's Breast Cancer Prevention (P-1) Study. A total of 11 064 women were randomly assigned to receive for 5 years daily doses of 20 mg of tamoxifen or placebo in the P-1 study, a multicenter, double-blind, placebo-controlled chemoprevention trial. Each woman was prospectively assessed for depression risk on the basis of medical history items collected at the baseline examination and placed in a high-, medium-, or low-risk group. Every 6 months, for a total of 36 months, the participants were assessed for depressive symptoms by completing the Center for Epidemiological Studies—Depression (CES-D) questionnaire. Scores of 16 or higher were indicative of an episode of affective distress. Differences between the risk groups and treatment arms were analyzed by logistic regression. Women in the higher risk depression groups were more likely to score 16 or higher on the CES-D (percent follow-up examinations with a score of ≥16: high-risk group = 35.7%, with 95% confidence interval [CI] = 32.5% to 38.9%; medium-risk group = 19.2%, with 95% CI = 18.1% to 20.3%; and low-risk group = 8.7%, with 95% CI = 8.3 to 9.1%) and to have these scores more frequently and for longer periods than women in the lower risk groups. Your order will be packed safe and secure and dispatched within 24 hours. This is exactly how your parcel will look like (pictures of a real shipping item). It has a size and a look of a regular private letter (9.4x4.3x0.3 inches or 24x11x0.7cm) and it does not disclose its contents I prefer not to take generics of Nolvadex if I can buy the original Nolvadex online from the certified company. The seller cares about its name and image and makes a quick delivery. As for me, I also prefer the original rather than analogues of the same drug. The principles of effectiveness are different, and there might be more side effects. I take Nolvadex only online, as I already trust the company, and they deliver it without any problems. I was afraid of side effects of Nolvadex, but, actually, I didn’t face them at all. I’ve been taking Nolvadex for a few months, and it has a good effect on me. How to purchase viagra in australia Cheap viagra from china Duloxetine brand I’ve also had women tell me their hot flashes are so bad they can’t function.” “Tamoxifen can cause a number of side effects, and some women choose to stop it prematurely for that. Tamoxifen Does Not Cause Depression. From the WebMD Archives. Nov. 6, 2001 -- There's been concern in recent years that the powerful breast cancer drug tamoxifen may cause or worsen depression. Oct 16, 2018. Tamoxifen's selective estrogen activation effects can cause some serious side effects, including blood clots, stroke, and endometrial cancer. Live4them wrote: Hello ladies I started Tamoxifen in January 2016 , didn't have to many side effects in the beginning except hot flashes .. A few months in my Onco suggested Effexor for hot flashes .. I took it for a few months with less hot flashes all was good in the world .. Then last month I noticed hot flashes coming back and worse , spoke to my doctor and after looking at my labs he said my ovaries weren't producing any estrogen . I looked post menopausal according to labs , mind you I had a period just the month before .. I didn't want to in fact I didn't want to take the Efferor any more . So I got off Effexor ( against my oncos advice ) Now I'm feeling super sad and emotional . All I do is cry and don't feel like getting out of bed ( which isn't an option ) so my question is , anyone feel like the tamoxifen makes you sad and depressed or is it the lack periods and estrogen and regular BC bull crap .. Two summers ago I dropped down to the 37 mg very slowly by removing a few extra tiny white beads (5 extra each week). May 31, 2016 AM Live4them wrote: Yes I weaned off Effexor , but I did do it a little fast maybe , I skipped doses and then took less of it every other day .. Just to let you know that tamoxifen can cause depression. I don't think it is common at all but it happened to me. I'm really glad to have read about Tamoxifen reactions in these posts. I was on Effexor for depression already but it wasn't enough for the new depression from the tamoxifen. I was doing fine before I started tamoxifen and then it happened quite gradually so I didn't really realize what was going on for quite awhile. I feel better prepared to manage things when I start taking it. My oncologist took me off tamoxifen and I think I'm starting to feel a little better but he also wants me off the Effexor. Perhaps I'll alert my family to what you've said here so they can remind me about what's happening if I start getting depressed. And back on Zoloft which I used to take before starting tamoxifen. But then I'll have nothing for hot flashes which have been bad anyway. If he is taking you off tamoxifen is he going to give you another treatment pill? I was told I need to take the tamoxifen for 5 years to increase my chances of not getting a recurrence so I am wondering that if he takes you off of that and does not give you something else then your percentage of a recurrence will go up. 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My PCP sent me to a psychiatrist that kept prescribing me different anties every month all the while I kept asking for Effexor, which I finally got. Effexor 150 mg did help me the entire time I was on Tamo had to quit after 4 years - Tamo. If tamoxifen-associated depression were the primary cause of these missing data, we would have predicted a positive dose–response increase in the magnitude of the ORs from the lowest to the highest depression risk group.