Tamoxifen for breast cancer

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  1. Kukunin New Member

    Tamoxifen for breast cancer


    Some types of breast cancer are affected by hormones in the blood. ER-positive and PR-positive breast cancer cells have receptors (proteins) that attach to estrogen, which helps them grow. There are different ways to stop estrogen from attaching to these receptors. Hormone therapy is a form of systemic therapy, meaning it reaches cancer cells almost anywhere in the body and not just in the breast. It's recommended for women with hormone receptor-positive (ER-positive and/or PR-positive) breast cancers, and it does not help women whose tumors are hormone receptor-negative (both ER- and PR-negative). Hormone therapy is often used after surgery (as adjuvant therapy) to help reduce the risk of the cancer coming back. Sometimes it is started before surgery (as neoadjuvant therapy) as well. Hormone therapy can also be used to treat cancer that has come back after treatment or that has spread to other parts of the body. Tamoxifen is one of the most common hormonal therapies for hormone-receptor-positive breast cancers (cancerous cells that feed off of certain hormones in the body). It’s usually taken as a pill once a day under the brand name Nolvadex. However, for people who have difficulty taking pills it can be given in a liquid form called Soltamox. Tamoxifen is often administered after surgery (as adjuvant therapy) to help reduce the risk of the cancer coming back. Sometimes it is started before surgery (as neoadjuvant therapy) as well. Tamoxifen works by blocking/stopping the effects of estrogen in a person’s breast tissue. This is because hormone-receptor-positive breast cancer feeds on hormones (like estrogen or progesterone) to grow.

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    Tamoxifen, also known by the brand name Nolvadex, is one of the more commonly prescribed medications to prevent breast cancer recurrence, and when used appropriately, may reduce the risk of recurrence of breast cancer coming back by roughly 50 percent. Dec 3, 2018. In a multicenter study, only 1 in 5 women at increased risk of breast cancer reported a strong need for tamoxifen preventive therapy, according. Tamoxifen is an effective and most appropriate agent for some women with breast cancer. But other forms of breast cancer treatment exist and can be more appropriate than tamoxifen for some women.

    For some women with breast cancer, taking adjuvant tamoxifen (Nolvadex®) for 10 years after primary treatment leads to a greater reduction in breast cancer recurrences and deaths than taking the drug for only 5 years, according to the results of a large international clinical trial. The findings from the ATLAS trial—presented at the San Antonio Breast Cancer Symposium (SABCS) and published in on December 5, 2012—are likely to change clinical practice, several researchers said. Nearly 7,000 women with early-stage, estrogen receptor-positive breast cancer were enrolled in the trial between 19. After taking tamoxifen for 5 years, participants were randomly assigned to continue taking tamoxifen for another 5 years or to stop taking it. From 5 to 9 years after the women began tamoxifen therapy, there was little difference in outcomes between the two treatment groups. This finding is consistent with those from other trials of adjuvant tamoxifen therapy, which showed that 5 years of tamoxifen can substantially reduce the risk of the cancer returning and of cancer death in the next few years, what one of the trial investigators, Richard Gray, MSc, of Oxford University, UK, called a "carryover effect." The improved outcomes with longer tamoxifen use emerged only after the 10-year mark, Gray explained during an SABCS press briefing. Among the women who took tamoxifen for 10 years, the risk of breast cancer returning between 10 and 14 years after starting tamoxifen was 25 percent lower than it was among women who took it for 5 years, and the risk of dying from breast cancer was nearly 30 percent lower. In this week’s issue of People, former Victoria’s Secret model Jill Goodacre opens up about her five-year battle with breast cancer and the medication she’s been on to keep the disease at bay. Goodacre, who’s married to singer and actor Harry Connick Jr., went through surgery and radiation in 2012 after a tumor was detected via sonogram, and has taken the drug tamoxifen ever since. As she approaches her five-year cancer-free mark, Goodacre says she’s looking forward to stopping tamoxifen. The medication can cause side effects, including weight gain, which Goodacre admits she’s struggled with. “I’ve always been a pretty fit person, and so to be just rounder and heavier and not to really be able to do much about it—that’s been hard,” she told People. “It’s taken a lot out of my self-confidence.” That’s a common problem among breast cancer survivors, says Nikita Shah, MD, medical director of the Cancer Risk Evaluation Program at Orlando Health UF Health Cancer Center. Shah has not treated Goodacre, but does prescribe tamoxifen to many of her own patients.) Still, tamoxifen can be lifesaving, says Dr. Shah, and for many women, its benefits outweigh its potential side effects.

    Tamoxifen for breast cancer

    Tamoxifen What You Need To Know Rethink Breast Cancer, Women Show Hesitancy About Tamoxifen, Even if at Increased Breast.

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  5. Oct 25, 2016. After an abnormal biopsy, Kathleen Gahm began taking tamoxifen to reduce her breast cancer risk. Learn why she's glad she made this.

    • Why I'm taking tamoxifen to avoid breast cancer MD Anderson..
    • Tamoxifen Helps Prevent Breast Cancer, But. -.
    • Tamoxifen for women at high risk of breast cancer - NCBI - NIH.

    Dec 10, 2018. Tamoxifen is a selective estrogen receptor modulator SERM used to treat hormone receptor-positive breast cancer and to prevent risk of. Abstract. In most developed and many developing countries, breast cancer is the most frequent cancer and the leading cause of cancer death among women. Oct 15, 2018. Tamoxifen, also known as Nolvadex, is a type of hormone therapy that is most effective on HR+ hormone receptor-positive breast cancers.

     
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